[Nle4] a-MSH, amide

Amylin, amide, human TFA, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis.

BI-0474 是一种强效的 KRASG12C 抑制剂，其对 GDP-KRAS::SOS1 蛋白-蛋白相互作用的IC50 值为 7.0 nM。BI-0474 对携带 G12C 突变的 NCI-H358 细胞具有较好的抗增殖活性。BI-0474 还在非小细胞肺癌异种移植模型中显示出较好的抗肿瘤活性。